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A revolutionary treatment which could provide hope for thousands
of people with wounds that will not heal is being made available
in the UK.
Promogran consists of a combination of collagen and a special form
of cellulose which acts upon the enzymes that cause chronic wounds.
Applied to a leg ulcer or pressure sore, it prevents the wound
from developing further while promoting healing.
Chronic wounds occur when enzymes called proteases, which break
down and dispose of dead or unwanted tissue, go into overdrive.
As a result, healing tissue, and proteins that encourage healing,
may be destroyed.
The process is often associated with underlying conditions, such
as poor circulation and diabetes.
About one in 50 of the elderly population is affected by leg ulcers,
and chronic wounds are also common in diabetics, many of whom are
plagued by sores on their feet.
Professor Keith Harding, from the Wound Healing Research Unit at
the University of Wales College of Medicine, Cardiff, said Promogran
could mean major long-term savings for the NHS.
The treatments come in two sizes costing £4.75 or £14.24
and may have to be applied every day or so for several weeks, but
this had to be weighed against the much higher cost of repeated
hospital admissions and wound dressings.
Promogran works by binding and de-activating the excess harmful
proteases. It also binds and protects growth factors, chemicals
that promote tissue regeneration.
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