Last Update: August 1, 2018 at 11:39 am

SOURCE: News for the Soul

DATE:   August 1st, 2018

 

All About Alzeihmers & Other forms of Dimentia

 

by Dr Holly

heard Wednesdays at Noon PST on

News for the Soul Radio

 

There are many types of dementia, not just Alzheimer’s.

We all know that we have a significantly aging population. The highest ratio of seniors than ever before. Well, I would dispute that a bit. The ratio of seniors to young people and children probably correlates with the number of battles and wars that are going on in a given time period, but that is a whole different story.

The concern here, is that with the higher concentration of seniors, we have a significant number of dementias diagnosed. Most people are familiar with Alzheimer’s, but many think that is the only form of dementia which is definitely not true.

There are many different types of dementia and of course many different causes. There is a tremendous overlap of symptoms and consequently different types of diagnostic processes and protocols and recovery or maintenance processes. So let’s take a look at the most common and be aware of how they are similar and how they are different so that when you take a loved one in for an assessment, you have a good background to work with. We will start with the understanding from Western Conventional Medicine – symptom management perspective, then we will look at a variety of other issues dealt with in REAL medicine.

  1. Alzhemier’s

  • Causes
    • Affects the entire brain as opposed to FTD that affects frontal & temporal lobes
    • Short term memory impairment, like most dementias, long term memory stays the longest
    • Accumulation of beta amyloids
    • Mitochondrial dysfunction and oxidative stress – glutathione
    • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925259/
  • Assessment:
    • Memory
    • Blood test for microRNAs, fats and proteins, beta amyloid proteins
  • Sx include:
    • Cognition:
      • Memory: forgets but then remembers
      • Learning: affects ability to learn new tasks, ie., working with the remote control; new card games, etc
      • Time and place orientation, i.e., knowing where you are – getting lost when they are out walking or driving, but will figure it out in earlier stages
      • Driving capacity: affects ability to read, judging distance, color contrast; people with early stages may still be able to drive
      • Conversation – they have difficulty following a conversation – but this may also be indicative of hearing issues; repeat themselves; finding the right word; call things by the wrong name
      • Organization: affects the capacity to know/remember where to put things; how to organize things;
      • Decision making capacity – can’t work a decision through; get stuck in a given component of the decision-making process: poor judgement
    • Emotions:
      • Affects various emotions: irritability, suspiciousness, depressed, fearful, anxious
      • Affects how they handle social situations; easily upset when out of their comfort zone
    • Behavior
      • Affects grooming and hygiene – although this is usually in later stages
      • Withdraws socially
      • Stop engaging in their favourite hobbies, work projects, etc
      • Requires more sleep – fatigue

 

  1. Creutzfeldt-Jakob disease

  • Causes:
    • unknown but 1% might include chromosome 20; abnormal prions – abnormal strings of proteins (amino acids) that fold themselves into 3 dimensional shapes and cause interruptions in the brain
    • still considered relatively rare
  • Sx include:
    • Affects mood: depression, apathy, mood swings, agitation and irritation
    • Affects cognition: confusion, disorientation, memory, planning, judgement, thinking
    • Affects muscular control: walking, muscle stiffness, twitches, involuntary jerky movements
    • There are 3 types:
      • Sporadic – appears despite there being no known risk factors
      • Hereditary – family history test positive
      • Acquired – transmitted typically through a medical procedure – although it is not considered contagious

 

  1. FTD – frontal temporal degeneration – actually an umbrella term for a number of dementias that occur in the frontal temporal lobes of the brain

  • Causes:
    • The frontal and temporal lobes atrophy or wastes away
    • Abnormal tau protein (Pick’s bodies) collect
    • About ¼ occur because of genetic mutations
    • Newer research reveals mitochondrial dysfunction https://scinapse.io/papers/2137076271
  • Assessment is typically an MRI – magnetic resonance imaging
  • Sx include:
    • Behaviorally
      • Socially inappropriate behavior
      • Tactless comments
      • Lack of insight or empathy
      • Distractibility
      • Increased interest in sex
      • Changes in food preferences
      • Poor hygiene
      • Repetitive comments or behaviors
      • Low energy
      • Poor motivation
      • Flat/blunted affect
    • Communication
      • Both expressive speech and receptive speech
      • Trouble finding the right word
      • Speak hesitantly and slowly
      • Hard time reading and writing – concentration I think
      • Difficulty forming sentence
    • Movement
      • Inability to control movement/motor actions – not parkinsonian
      • Fall frequently – able to catch himself, but his right leg often gives out
    • However, memory and space/location doesn’t tend to change
    • 4 types:
      • Behavioral variant frontotemporal dementia
        • Socially inappropriate interactions
        • Inappropriate emotions
      • Primary progressive aphasia
        • Impairment in communication skills/language ability
        • Both to communicate and to understand
      • Progressive supranuclear palsy
        • Affects balance and movement – intermittent
        • Affects cognitive capacity – intermittent
        • Affects eye movement – intermittent – thought he was having TIAs
      • Corticobasal degeneration
        • Affects muscle causing weakness and tremors – usually start on one side of the body
        • Problems with memory and behavior develop as the disorder develops

 

  1. Korsakoff syndrome

  • Causes:
    • B1 deficiency thus associated with Wernicke’s encephalopathy
    • alcohol and AIDS and trauma to the brain are also known to cause it
  • Sx include:
    • Affects ability to learn
    • Affects memory both STM & LTM
    • Confabulates – note the difference between justification and rationalization and confabulation

 

  1. Lewy body syndrome – now considered only second to Alzheimer’s

  • Cause:
    • Lewy bodies can have an accumulation of the alpha-synuclein protein and/or other proteins (ubiquitin, neurofilament protein, alpha B crystallin)
      • Lewy neurites – abnormal neurites in diseased neurons containing granular material and abnormal alpha synucleinopathies like lewy bodies
    • Sx include:
      • Affects cognition: memory (more prominent in Alzheimer’s in early stages), thinking, reasoning, confusion, alertness all of which can vary throughout the day
      • Affects musculature: hunched posture; rigid muscles; Parkinsonian shuffle; trouble initiating movement, balance
      • Visual hallucinations &/or trouble interpreting visual information
      • Acting out dreams
      • Malfunctioning of the autonomic nervous system
      • Delusions

 

  1. Normal pressure hydrocephalus

  • Cause:
    • Excess cerebrospinal fluid accumulates in the brain’s ventricles
  • Sx include:
    • Affects cognition: thinking, reasoning, decision making, reduced concentration
    • Affects personality and behavior
    • Affects muscular control: walking (body bent forward, legs held widely apart, feet glued to the floor), bladder control

 

  1. Parkinson’s

  • Causes:
    • Deposits of alpha synuclein and or other compounds
  • Sx include:
    • Cognition:
      • Affects memory & concentration
      • Affects decision making and good judgment
      • Difficulty interpreting speech
    • Emotions:
      • Affects depression and anxiety
      • Irritability and anxiety
    • Physically
      • Muffled speech
      • Visual hallucinations
      • Paranoid thinking
      • Sleep disturbances
      • Postural instability and gait disturbance
    • Behaviorally
      • Cognitive issues like memory usually appear within a year of movement disorders

 

  1. Pick’s disease (Picks is a type of frontotemporal disease – it affects frontal and temporal lobes)
  • Causes:
    • tau proteins interrupting neural functioning and causing cellular death; brain shrinks
  • assessment involves:
    • memory assessment
    • functional capacity – SPECT
    • MRI
  • Sx include:
    • Cognition:
      • Upper management cog skills: planning, strategy, objective perspective, critical analysis, etc
      • Reduce ability to read or write
      • Shrinking vocabulary
      • Accelerated memory loss
    • Emotion: emotional control is lost; abrupt mood changes; depressive like behavior
    • Physically: physical weakness
    • Behavior: repetitive, compulsive or inappropriate behavior; social withdrawal; declining personal hygiene

 

  1. Posterior cortical atrophy

  • Causes:
    • gradual but progressive degeneration of the outer posterior layer of the brain
    • due to amyloid plaques – sticky accumulates of the amyloid proteins which divides and becomes toxic to the brain, they occur outside of the nerve cells, neurofibrillary tangles
  • Sx include:
    • Visual processing: affects issues like reading, judging distance, distinguish between moving objects/stationary objects; disorientation; use of tools or common objects
    • Hallucinations
    • Difficulty performing math or spelling
    • Emotionally: anxiety
    • Cognition: memory affected in later stages

 

  1. Vascular dementia

  • Causes:
    • inadequate blood flow
    • TIAs – see below
    • Single infarct dementia – where cells have died due to lack of blood flow – usually due to a large ischemic stroke
    • Multi infarct dementia – several ministrokes over time causing spots of damage throughout the brain
    • Subcortical dementia – occurs when small arteries deep in the brain are blocked
    • Mixed vascular dementia – when two or more types are involved – the dominant type will determine the protocol to follow
  • Assessment:
    • Blood pressure
    • Blood sugar
    • Cholesterol
    • Balance & coordination
    • Muscle tone and strength
    • Ability to stand, walk
    • Reflexes
    • Sense of touch/sight
    • Thyroid disorders
    • Vitamin deficiencies
    • CT or MRI
  • Sx include:
    • Affects cognition:
      • progressive deterioration, although some cycle with improving then deteriorating
      • challenges with thinking interfering with daily activities
      • planning and organizing
      • slowness and/or confusion
      • concentration
      • verbal fluency
      • abstract reasoning
      • attention
      • orientation
    • Affects urinary incontinence
    • Affects emotion:
      • apathy in early states
      • depression
      • anxiety
      • rapid mood swings
      • unusually highs or lows like in bipolar disorders
  1. TIAs aka transient ischemic attack – a form of vascular dementia

  • Causes:
    • An ischemic stroke is caused by a blood clot blocking a blood vessel
      • High blood pressure
      • High levels of certain cholesterols
      • Cardiovascular disease
        • Carotid artery disease
        • Peripheral artery disease
      • Diabetes
        • High levels of sugars
        • High levels of AGEs
        • High levels of homocysteine (an amino acid in the blood that causes arteries to thicken and scar)
      • Excess drinking, illicit drugs
      • Use of oral contraceptives
    • If it is a transient, momentary blockage – then it is called a transient ischemic attack – symptoms may only be momentarily but not longer than 24 hours
    • One study of 5514 people identified that rates of dementia increased between 9.6 and 14.4% in people who had one stroke; 29.6-53.1% in people with more than one stroke
    • People who are in a high stroke risk category also have a higher risk of dementia even without a stroke
  • Assessment:
    • Physical examination
    • Blood pressure and cholesterol levels
    • Diabetes
    • Homocysteine – blood test
    • MRI – to show neural changes; rule out strokes
    • MRI or CT scan – to determine which blood vessels are blocked or bleeding
  • Symptoms:
    • Cognition: slurred speech, garbled speech, difficulty understanding others
    • Physically:
      • Weakness
      • Numbness
      • paralysis in the face/arm/leg – typically on one side of the body
      • loss of balance or coordination, i.e., your leg gives out
      • generalized tingling in the arms or legs
    • Vision: blindness in one or both eyes
    • Sudden headache

 

 

From an alternative or REAL medicine perspective, we look at the following causes:

 

Sugars and AGEs:

  • High levels of sugar are toxic to the whole body including the brain
  • AGEs or glycotoxins that we cook or make in our bodies – cooking sugars at high temperatures with fats or proteins – lead to diabetes and hypertension and dementia

 

Heavy metal detoxification

  • Aluminum first recognized in causing Alzheimer’s
    • In cooking pots, deodorant, tin foil, soda cans, cake mixes, milk formulas and water
      • Decreases the metabolism of proteins used in brain cells which leads to accumulation and plaques
      • Crosses the blood brain barrier and causes plaquing in the brain
    • Other heavy metals include:
      • arsenic (chicken, rice, water), mercury (teeth)
      • lithium (water, grains, vegetables, mustard, kelp, meat)
      • lead (household dust, old paint, water pipes, canned foods, pottery/ceramics, eye liner and lipstick)
      • mercury (medications – immunizations, vaccinations and dental amalgams)
      • manganese toxicity (miners)
      • bismuth (pepto-bismul – looks like Creutzfeld Jakob dx found in ) – all lead to cognitive decline https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038529/
    • Food additives:
      • DA or diacetyl – gives buttery flavour, also used in wines, beer, milk products, margarine and chips – structure is very similar to the beta amyloid protein plaques and tangles found in brains with dementia
      • Nitrosamines found in smoked meats
      • Nitrites found in beer

 

Medications that cause dementias:

Anti-anxiety drugs – benzodiazepines prescribed for insomnia, depression, anxiety, agitation – inhibit activity in key parts of the brain

Anti-depressant drugs – tricyclic antidepressants

Antihistamines – relieve allergy symptoms; motion sickness; nausea, vomiting, dizziness, anxiety, insomnia – inhibit the neurotransmitter acetylcholine that regulates a wide range of functions in the body including memory and learning centers in the brain

Anti-seizure drugs – prescribed for seizures, nerve pain, bipolar, mood disorders – again inhibit activity in the brain

Incontinence drugs- prescribed for an overactive bladder but block another neurotransmitter acetylcholine

Narcotic pain killers – prescribed for chronic pain and rheumatoid arthritis – blunt emotional response to pain and impacts on the neurotransmitters that work with cognition

Parkinsonian drugs – dopamine agonists prescribed for Parkinson’s, pituitary tumors, restless leg syndrome – provoke activity in the dopamine pathways – side effects of increased experience of pleasure but loss of fine motor control, learning and memory, confusion, delusions, hallucinations, etc

Sleeping pills – nonbenzodiazepines – act on same pathways as benzodiazepines and can produce problems with addictions and withdrawal

Statins – anti-cholesterol drugs; lipids/fats/cholesterols are hugely important to every cell in the body including the brain; 3 / 4 people taking these drugs have problems with cognition and studies show they improve when they stop taking the drugs

Steroids – long known to induce cognitive and emotional effects called steroid dementia

Hi blood pressure drugs – beta blockers – interfere with neurotransmitters like norepinephrine and epinephrine

 

The specific type of dementia determines the treatment protocol. With some dementias, we can actually reverse them; with others we can prevent or slow down the progress; with some we can only manage them.

 

We can use foods and supplements that contain PQQ

Foods: many food deficiencies can cause dementia

  • Omega 3s: 70% of the brain is fat – we need those healthy fats
  • Nuts and seeds: walnuts, almonds, pecans
  • Salmon, mackerel, oysters, sardines
  • Avocados
  • Anti-oxidants – the brain needs to be protected against free radicals with anti-oxidants – glutathione
  • Berries
  • Green leafy vegetables
  • Dark chocolate
  • Vitamin D3 – important to brain function in the hippocampus (STM – LTM) and the central nervous system regulating various neurotransmitters synthesis and nerve growth and protects against neural inflammation; important to cognitive function and emotional stability
    • Fatty fish: tuna, mackerel, trout
    • Cheese
    • Egg yolks
  • Pre and probiotics

Herbs:

  • Ashwagandha, burdock root, cilantro, dandelion, ginkgo biloba, ginseng , milk thistle, neem, red clover, sage, stinging nettle, turmeric – note: if you are using these, make sure you are working with a registered herbalist and utilizing the right amounts/ratios/combinations for your particular issue

 

Supplements:

  • B9 &/or 12
  • Iron
  • PQQ

 

Ayurveda: Panchakarma treatments

 

References:

https://www.webmd.com/alzheimers/types-dementia#2

https://www.alz.org/alzheimers-dementia/what-is-dementia/types-of-dementia

https://www.verywellhealth.com/what-is-frontotemporal-dementia-98747

https://en.wikipedia.org/wiki/Vascular_dementia

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038529/

https://www.scientificamerican.com/article/does-d-make-a-difference/

https://www.linkedin.com/pulse/heavy-metals-link-alzheimers-disease-senile-dementia-harry-khuman

 

 

 

 

noon pacific:

TODAY:   All About Alzheimer’s and other types of Dimentia…

Wednesdays at NOON PST  / 3PM EST – The Whole Health Initiative with Dr Holly – BASED IN CANADA – AN NFTS GLOBAL LUMINARY SINCE MARCH 2014 – Dr. Holly is a Doctor of Natural Medicine, a scientist, a professional speaker, an author of Cancer: Why what you don’t know about your treatment could harm you and 12 other books and a practitioner.  As a Doctor of Natural Medicine with 7 degrees & 3 designations in a wide range of healing modalities and 20 years experience, she can assist you in identifying and understanding your path to health. She can identify your underlying life themes, coping mechanisms, value systems and defense mechanisms to understanding the physiology and biochemistry and energy patterns of your body.  She has a mobile health clinic that comes to your door and can assess 1000s of variables in front of you AND create a protocol unique to you.  In addition, she provides consultation for physicians and clients around the world.