All about Beta Amyloids

Last Update: August 14, 2019 at 12:04 pm

SOURCE:  Nfts

DATE:  August 14, 2019

 

 

All about Beta Amyloids

by Dr Holly

 

Heard Wednesdays at noon pacific on NFTS:

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Wednesdays at NOON PST  / 3PM EST – The Whole Health Initiative with Dr Holly  – An NFTS Global Luminary  broadcasting from Canada since March 2014 –   Dr Holly is a Doctor of Natural Medicine, a scientist, a professional speaker, an author of Cancer: Why what you don’t know about your treatment could harm you and 12 other books and a practitioner.  As a Doctor of Natural Medicine with 7 degrees & 3 designations in a wide range of healing modalities and 20 years experience, she can assist you in identifying and understanding your path to health. She can identify your underlying life themes, coping mechanisms, value systems and defense mechanisms to understanding the physiology and biochemistry and energy patterns of your body.  She has a mobile health clinic that comes to your door and can assess 1000s of variables in front of you AND create a protocol unique to you.  In addition, she provides consultation for physicians and clients around the world.

Do you know what beta amyloids are? They are important to most of us….

Amyloids are groups of proteins that fold into shapes that cause disruptions in the body. Consequently, they are associated with over 50 different diseases and dysfunctions. https://en.wikipedia.org/wiki/Amyloid

Beta amyloids are a particular group of amyloid proteins that unfold and cause issues like Alzheimer’s and insulin resistance that is associated with Type 11 diabetes.  WOW!! Can we prevent it? Yes! That’s an even bigger WOW!!

So while different types of amyloids are involved in a variety of different diseases, let’s just focus on Alzheimer’s.

We all know that preventative medicine is a lot cheaper and much more effective than reactive medicine. So, let’s figure this out.

First off, let’s look at some basic statistics regarding beta amyloids:

  1. More than 30 million people in the world suffer from dementia – that’s a lot of people
  2. More than 285 million people in the world suffer from diabetes – that’s even more people
  3. Studies are now showing that most people who suffer from Alzheimer’s have a glucose intolerance
  4. Beta amyloids – yes that’s the title of the article – affect the pancreas, insulin receptors and the brain!! Oh wow – no wonder there is a link

So, does diabetes cause Alzheimer’s or does Alzheimer’s cause diabetes or does beta amyloids cause both? Hmmm.

Research back in 1994 suggested that there was a connection between AGEs and amyloids, but then in 1995, another research study said they were not associated – interesting that there is a huge gap between then and the study that occurred in 2015 – showing that AGEs definitely do increase beta amyloids and do so through ROS – or free radicals. Both the AGEs and the amyloid precursors are toxic to the brain and both destroy compounds that protect the brain.

Okay so all that might not be of interest to you except that excess sugars cause the body to make compounds that are seriously detrimental to the brain and can cause diabetes type II. But you may be interested in how you can prevent all that from happening.

There are a major class of natural compounds called flavonoids that prevent/inhibit the body from making those protein compounds called amyloids, by targeting a protein called an “amyloid precursor protein”.

If you are interested, polyphenols are a large group of phytonutrients. The have a huge number of sub and sub subcategories. The primary group are the different types of polyphenols which include:

  1. flavonoid
  2. phenolic acids
  3. stilbenes
  4. lignans

Now let’s break down flavonoids: flavones, anthocyanidins flavanones, isoflavones, flavanols, flavonals

Then we can break down the anthocyanidins: catechins, delphinidin, pelargonidin, peonidin, petunidin, and malvidin

We can go even further and break down the catechins: epicatechins, EGCG, ECG, EC.

Would you believe, we can even break these down further. But I think you get the drift. When we are looking at the polyphenols, there is an incredible amount to understand. So let’s get back to some of the more general categories, that you may have heard of.

Some more commonly recognized flavonoids are:

**Flavanols and catechins are now recognized to prevent beta amyloid production by targeting the required enzyme: beta-secretase.

https://www.alzheimers.org.uk/research/our-research/research-projects/flavonoids-diet-could-they-help-prevent-alzheimers-disease

And of course, because it is Dr Holly, we cannot forget the impact of glutathione. Glutathione protects the brain from oxidative stress. By far the most powerful anti-oxidant. It needs to be produced in every cell in the body. AND…it also works with the plasminogen system (an enzyme system that controls proteins involved in fibrin)  to inhibit the formation of amyloids. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640603/

When it comes to diabetes, these amyloids also can play a part. They destroy the beta Langerhans cells that secrete insulin in the pancreas. Oh darn. Now it is a different type of amyloid that we were talking about with regards to the brain. This one is called, islet amyloid polypeptide (IAPP). https://phys.org/news/2016-07-role-amyloids-ii-diabetes.html

In fact, now they are linking the two types of amyloids. How one type of amyloid can in effect drop seeds into another area causing even wider spread issues.  If you want to go even further in depth, read this article: https://www.elsevier.com/about/press-releases/research-and-journals/amyloid-formation-may-link-alzheimer-disease-and-type-2-diabetes

Bottom line? If we eat whole, real, healthy foods, we not only prevent diabetes but a variety of chronic disorders including dementias like Alzheimer’s.

References:

https://en.wikipedia.org/wiki/Amyloid#Diseases_featuring_amyloids

https://diabetes.diabetesjournals.org/content/62/4/1005

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC43869/pdf/pnas01133-0166.pdf  (1994)

https://www.ncbi.nlm.nih.gov/pubmed/7612872 (1995)

https://dm5migu4zj3pb.cloudfront.net/manuscripts/116000/116696/JCI93116696.pdf

https://www.ncbi.nlm.nih.gov/pubmed/26587989  (2015)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654523/ (2015)

https://www.tandfonline.com/doi/full/10.1080/10942912.2017.1354017?scroll=top&needAccess=true

https://www.alzheimers.org.uk/research/our-research/research-projects/flavonoids-diet-could-they-help-prevent-alzheimers-disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128063/